The Link Between Cancer Stem Cells and Immunotherapy Resistance

Despite significant breakthroughs in immunotherapy , many cancer patients experience resistance , either initially (primary resistance) or after an initial response (acquired resistance). A growing body of research points to a major culprit behind this resistance: Cancer Stem Cells (CSCs) . Understanding the connection between cancer stem cells and immunotherapy resistance could unlock new strategies for overcoming treatment failure and achieving lasting remission in cancer patients. What Are Cancer Stem Cells? Cancer Stem Cells (CSCs) are a subpopulation of cancer cells that possess characteristics similar to normal stem cells. These include: Self-renewal Differentiation Tumor initiation Unlike the bulk of tumor cells, CSCs are often dormant or slow-dividing , making them more resistant to chemotherapy, radiation , and, as recent studies suggest, immunotherapy . How Do Cancer Stem Cells Resist Immunotherapy? Immunotherapy, including checkpoint inhibitors,...